The Impact of Cirrhosis on Transgender Individuals
Cirrhosis is a chronic, progressive end-stage liver disease that occurs when scar tissue prevents the liver from functioning normally. While studies have shown that two of the leading causes of cirrhosis — alcohol use disorder and viral hepatitis — occur more frequently in transgender individuals, there has been little research examining if these risk factors translate into greater incidences of cirrhosis among transgender patients.
A new study from Keck Medicine of USC published in The American Journal of Gastroenterology sheds light on this issue. The study reveals that transgender adults have double the prevalence of cirrhosis compared to cisgender adults, highlighting a pressing health issue that needs addressing. Dr. Brian P. Lee, a hepatologist and liver transplant specialist with Keck Medicine, and principal investigator of the study, emphasizes the importance of providing scientifically backed liver health guidance for physicians to offer transgender patients a higher level of care.
Aside from the higher prevalence of cirrhosis in the transgender population, the study also uncovered other concerning trends. The majority of transgender adults with cirrhosis have a diagnosis of anxiety and/or depression, alcohol was identified as the leading cause of cirrhosis in the transgender group, and they also had higher rates of viral hepatitis and were more likely to have HIV/AIDS compared to cisgender patients.
Possible reasons behind the disparity
The study’s authors hypothesize that the increased rates of depression and anxiety among transgender individuals may be driving higher rates of alcohol use, leading to greater instances of cirrhosis. The higher rate of HIV/AIDS among transgender patients may also contribute to liver disease progression. Additionally, lack of access to quality healthcare could play a role in the disparities observed.
The study also looked at the five-year outcomes among all transgender and cisgender patients with cirrhosis. Despite differences in the two groups, the study found that the number of negative outcomes of cirrhosis was the same, indicating a need for early prevention and intervention in the transgender community.
To reach their conclusions, the researchers analyzed data from a large national database containing medical claims for over 60 million patients. By comparing incidences of cirrhosis, causes of the disease, and tracking depression and anxiety in patients, the study offers valuable insights into the healthcare needs of transgender individuals.
Dr. Lee and Dr. Kahn, co-author of the study, hope that this research will spark more studies and encourage healthcare practitioners to provide transgender patients with extra support, including liver screenings and access to mental health resources.
Keck Medicine’s Efforts to Support Transgender Patient Wellness
Keck Medicine has taken proactive steps to address the healthcare needs of the transgender population. The USC Gender-Affirming Care Program was launched to provide tailored, supportive healthcare services for transgender, non-binary, and gender-diverse individuals. The program offers a range of expert services including routine health care, gender-affirming hormone therapy, and surgery.
The program involves physicians from various disciplines, ensuring comprehensive care for transgender patients. Additionally, Keck Medicine hospitals have received recognition for their commitment to LGBTQ+ healthcare equality, demonstrating a dedication to inclusive and equitable treatment of all patients.
Overall, the study on cirrhosis among transgender individuals underscores the importance of addressing healthcare disparities and providing targeted support for this vulnerable population. By raising awareness and advocating for better healthcare practices, we can work towards improving the well-being of transgender patients and reducing the burden of liver disease in this community.
